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20

1

Astrocytic RNA editing regulates the host immune response to alpha-synuclein
Choi, Minee L., D`Sa, Karishma, Wagen, Aaron Z., Seto-Salvia, Nuria, Kopach, Olga, Evans, James R., Rodrigues, Margarida, Lopez-Garcia, Patricia, Lachica, Joanne, Clarke, Benjamin E., Singh, Jaijeet, Ghareeb, Ali, Bayne, James, Grant-Peters, Melissa, Garcia-Ruiz, Sonia, Chen, Zhongbo, Rodriques, Samuel, Athauda, Dilan, Gustavsson, Emil K., Taliun, Sarah A. Gagliano, Toomey, Christina, Reynolds, Regina H., Young, George, Strohbuecker, Stephanie, Warner, Thomas, Rusakov, Dmitri A., Patani, Rickie, Bryant, Clare, Klenerman, David A., Gandhi, Sonia, Ryten, Mina
SCIENCE ADVANCES, 2025

2

Prediction of mechanistic subtypes of Parkinson`s using patient-derived stem cell models
D`Sa, K[D`Sa, Karishma], Evans, JR[Evans, James R.], Virdi, GS[Virdi, Gurvir S.], Vecchi, G[Vecchi, Giulia], Adam, A[Adam, Alexander], Bertolli, O[Bertolli, Ottavia], Fleming, J[Fleming, James], Chang, HJ[Chang, Hojong], Leighton, C[Leighton, Craig], Horrocks, MH[Horrocks, Mathew, Athauda, D[Athauda, Dilan], Choi, ML[Choi, Minee L.], Gandhi, S[Gandhi, Sonia]
NATURE MACHINE INTELLIGENCE, 2023

3

Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons
Virdi, GS[Virdi, Gurvir S.], Choi, ML[Choi, Minee L.], Strohbuecker, S[Strohbuecker,, Evans, JR[Evans, James R.], Yao, Z[Yao, Zhi], Athauda, D[Athauda, Dilan], Nirujogi, RS[Nirujogi, Raja S., Wernick, AI[Wernick, Anna I.], Pelegrina-Hidalgo, N[Pelegrina, Leighton, C[Leighton, Craig], Saleeb, RS[Saleeb, Rebecca S.], Kopach, O[Kopach, Olga], Alrashidi, H[Alrashidi, Haya], Melandri, D[Melandri, Daniela], Perez-Lloret, J[Perez-Lloret,, Angelova, PR[Angelova, Plamena, Sylantyev, S[Sylantyev, Sergiy, Eaton, S[Eaton, Simon], Heales, S[Heales, Simon], Rusakov, DA[Rusakov, Dmitri A., Alessi, DR[Alessi, Dario R.], Kunath, T[Kunath, Tilo], Horrocks, MH[Horrocks, Mathew, Abramov, AY[Abramov, Andrey Y., Patani, R[Patani, Rickie], Gandhi, S[Gandhi, Sonia]
NPJ PARKINSONS DISEASE, 2022

4

Pathological structural conversion of alpha-synuclein at the mitochondria induces neuronal toxicity
Choi, ML[Choi, Minee L.], Chappard, A[Chappard, Alexandr, Singh, BP[Singh, Bhanu P.], Maclachlan, C[Maclachlan, Cath, Rodrigues, M[Rodrigues, Margar, Fedotova, E[Fedotova, Evgenia], Berezhnov, AV[Berezhnov, Alexe, De, S[De, Suman], Peddie, C[Peddie, Chris], Athauda, D[Athauda, Dilan], Virdi, GS[Virdi, Gurvir S.], Zhang, WJ[Zhang, Weijia], Evans, JR[Evans, James R.], Wernick, A[Wernick, Anna], Zanjani, ZS[Zanjani, Zeinab Sh, Angelova, PR[Angelova, Plamena, Esteras, N[Esteras, Noemi], Vinikurov, A[Vinikurov, Andrey, Morris, K[Morris, Katie], Jeacock, K[Jeacock, Kiani], Tosatto, L[Tosatto, Laura], Little, D[Little, Daniel], Gissen, P[Gissen, Paul], Clarke, DJ[Clarke, David J.], Kunath, T[Kunath, Tilo], Collinson, L[Collinson, Lucy], Klenerman, D[Klenerman, David], Abramov, AY[Abramov, Andrey Y., Horrocks, MH[Horrocks, Mathew, Gandhi, S[Gandhi, Sonia]
NATURE NEUROSCIENCE, 2022

5

The Impact of Type 2 Diabetes in Parkinson`s Disease
Lawton, M[Lawton, Michael], Gandhi, S[Gandhi, Sonia], Athauda, D[Athauda, Dilan], Morris, H[Morris, Huw], Grosset, D[Grosset, Donald], Foltynie, T[Foltynie, Thomas], Evans, J[Evans, James], Wernick, A[Wernick, Anna], Virdi, G[Virdi, Gurvir], Choi, ML[Choi, Minee L.], Vijiaratnam, N[Vijiaratnam, Ni, Girges, C[Girges, Christine], Ben-Shlomo, Y[Ben-Shlomo, Yoav, Ismail, K[Ismail, Khalida]
MOVEMENT DISORDERS, 2022

6

Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation
Angelova, PR[Angelova, Plamena, Choil, ML[Choil, Minee L.], Berezhnov, AV[Berezhnov, Alexe, Horrocks, MH[Horrocks, Mathew, Hughes, CD[Hughes, Craig D.], De, S[De, Suman], Rodrigues, M[Rodrigues, Margar, Yapom, R[Yapom, Ratsuda], Little, D[Little, Daniel], Dolt, KS[Dolt, Karamjit S.], Kunath, T[Kunath, Tilo], Devine, MJ[Devine, Michael J.], Gissen, P[Gissen, Paul], Shchepinov, MS[Shchepinov, Mik, Sylantyev, S[Sylantyev, Sergiy, Pavlov, EV[Pavlov, Evgeny, V], Klenerman, D[Klenerman, David], Abramov, AY[Abramov, Andrey Y., Gandhi, S[Gandhi, Sonia]
CELL DEATH AND DIFFERENTIATION, 2020

7

Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death
Hughes, C[Hughes, Craig], Choi, ML[Choi, Minee L.], Yi, JH[Yi, Jee-Hyun], Kim, SC[Kim, Seung-Chan], Drews, A[Drews, Anna], St George-Hyslop, P[St George-, Bryant, C[Bryant, Clare], Gandhi, S[Gandhi, Sonia], Cho, K[Cho, Kwangwook], Klenerman, D[Klenerman, David]
COMMUNICATIONS BIOLOGY, 2020

8

Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson`s disease pathogenesis
Hughes, CD[Hughes, Craig D.], Choi, ML[Choi, Minee L.], Ryten, M[Ryten, Mina], Hopkins, L[Hopkins, Lee], Drews, A[Drews, Anna], Botia, JA[Botia, Juan A.], Iljina, M[Iljina, Maria], Rodrigues, M[Rodrigues, Margar, Gagliano, SA[Gagliano, Sarah A, Gandhi, S[Gandhi, Sonia], Bryant, C[Bryant, Clare], Klenerman, D[Klenerman, David]
ACTA NEUROPATHOLOGICA, 2019

9

Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells
Zuo, YK[Zuo, Yukun], Spillantini, MG[Spillantini, M, Calo, L[Calo, Laura], Choi, ML[Choi, Minee-Liane], De, SM[De, Suman], Flagmeier, P[Flagmeier, Patric, Wirthensohn, DC[Wirthensohn, D, Kundel, F[Kundel, Franziska], Ranasinghe, RT[Ranasinghe, Roh, Sanchez, SE[Sanchez, Santiago, Athauda, D[Athauda, Dilan], Whiten, DR[Whiten, Daniel R.], Lee, SF[Lee, Steven F.], Dobson, CM[Dobson, Christopher, Gandhi, S[Gandhi, Sonia], Klenerman, D[Klenerman, David], Horrocks, MH[Horrocks, Mathew
CHEMBIOCHEM, 2018

10

Crucial role of protein oligomerization in the pathogenesis of Alzheimer`s and Parkinson`s diseases
Gandhi, S[Gandhi, Sonia], Choi, ML[Choi, Minee L.]
FEBS JOURNAL, 2018