Discovery of Diphenyl Ether Derivatives as Novel BKCa Channel Activators: Structure-Activity Relationship, Cryo-EM Complex Structures, and In Vivo Animal Studies
Soo Bin Park, Na Young Lee, Eun-Young Lee, Subin Kim, Narasaem Lee, Eun Chae Roh, Yoon Gyoon Kim, Hee Jin Kim, Mi Sun Jin, Chul-Seung Park, Yong-Chul Kim
Journal of Medicinal Chemistry, 2025
2
CRBN modulates synuclein fibrillation via degradation of DNAJB1 in mouse model of Parkinson disease
Uroos Akber, Jun-Hyung Jung, Heewoong Yoon, Jiwon Seo, Chul-Seung Park
npj Parkinson's Disease, 2024
3
Activation mechanism and novel binding sites of the BKCa channel activator CTIBD
Narasaem Lee, Subin Kim, Na Young Lee, Heeji Jo, Pyeonghwa Jeong, Haushabhau S Pagire, Suvarna H Pagire, Jin Hee Ahn, Mi Sun Jin, Chul-Seung Park
Life Science Alliance, 2024
4
Enhanced homeostatic sleep response and decreased neurodegenerative proteins in cereblon knock-out mice
Jun-Hyung Jung, Jinhong Kim, Uroos Akber, Na Young Lee, Jeong-won Baek, Jieun Jung, Mincheol Park, Jiseung Kang, Seungje Jeon, Chul-Seung Park, Tae Kim
Communications Biology, 2024
5
Effects of cereblon on stress-activated redox proteins and core behavior
Uroos Akber, Sunhwa Bong, Zee-Yong Park, Chul-Seung Park
Brain Research, 2022
6
Discovery and characterization of a potent activator of the BKCa channel that relives overactive bladder syndrome in rats
Heeji Jo, Eun Jung Bae, Narasaem Lee, Jae Won Kwon, Suhan Cho, Sung Joon Kim, Jin Hee Ahn, Chul-Seung Park
European Journal of Pharmacology, 2022
7
Cereblon Regulates the Proteotoxicity of Tau by Tuning the Chaperone Activity of DNAJA1
Uroos Akber, Heeji Jo, Seungje Jeon, Seung-Joo Yang, Sunhwa Bong, Sungsu Lim, Yun Kyung Kim, Zee-Yong Park, Chul-Seung Park*
The Journal of Neuroscience, 2021
8
Regulation of AMPK Activity by CRBN Is Independent of the Thalidomide-CRL4CRBN Protein Degradation Axis
Seung-Joo Yang, Seungje Jeon, Jeong Won Baek, Kwang Min Lee*, Chul-Seung Park*
Pharmaceuticals, 2021
9
Ablation of CRBN induces loss of type I collagen and SCH in mouse skin by fibroblast senescence via the p38 MAPK pathway
Seungje Jeon, Yi-Seul Yoon, Hyoung Kyu Kim, Jin Han, Kwang Min Lee, Jung Eun Seol*, Steve K. Cho*, Chul-Seung Park*
Aging, 2021
10
Identification and Characterization of a Novel Large-Conductance Calcium-Activated Potassium Channel Activator, CTIBD, and Its Relaxation Effect on Urinary Bladder Smooth Muscle
Narasaem Lee, Bong Hee Lim, Kyu-Sung Lee, Jimin Shin, Haushabhau S. Pagire, Suvarna H. Pagire, Jin Hee Ahn, Sung Won Lee, Tong Mook Kang, Chul-Seung Park*