Policy support for the promotion of the CG industry in Korea – focusing on evaluation of importance and priority
Ji‐Young Na
IF 1.7
Asian Journal of Technology Innovation
As the COVID-19 pandemic continues, online-based business models are growing rapidly, and the demand for computer graphic (CG) technology is increasing. To boost the invigoration of the CG industry through effective support, it is necessary to understand the factors to be considered in the domestic CG industry. Accordingly, this study developed evaluation indicators to be considered for the invigoration of this industry and weighed them using AHP analysis. Specifically, a draft was created based on literature review and expert consultation, and the indicators were determined using the two-time Delphi method. The three evaluation areas of research and development, cultivation of talented people, and fostering the industry include a total of 15 evaluation indicators. The AHP results showed that 'fostering the industry' was the most important one among the main factors, and 'fostering converged and combined workforce' was the most important one among the detailed factors. The content and results of this study are expected to be used as basic data to preferentially refer to when planning and supporting policies for the invigoration of the CG industry are established with the industry, academia, and research collaboration.
Zileuton Alleviates Radiation-Induced Cutaneous Ulcers via Inhibition of Senescence-Associated Secretory Phenotype in Rodents
Mineon Park, Ji‐Young Na, Seo Young Kwak, Sunhoo Park, Hyewon Kim, Sun‐Joo Lee, Won‐Suk Jang, Seung Bum Lee, Won Il Jang, Hyosun Jang, Sehwan Shim
IF 4.9
International Journal of Molecular Sciences
Radiation-induced cutaneous ulcers are a challenging medical problem for patients receiving radiation therapy. The inhibition of cell senescence has been suggested as a prospective strategy to prevent radiation ulcers. However, there is no effective treatment for senescent cells in radiation ulcers. In this study, we investigated whether zileuton alleviated radiation-induced cutaneous ulcer by focusing on cell senescence. We demonstrate increased cell senescence and senescence-associated secretory phenotype (SASP) in irradiated dermal fibroblasts and skin tissue. The SASP secreted from senescent cells induces senescence in adjacent cells. In addition, 5-lipoxygenase (5-LO) expression increased in irradiated dermal fibroblasts and skin tissue, and SASP and cell senescence were regulated by 5-LO through p38 phosphorylation. Finally, the inhibition of 5-LO following treatment with zileuton inhibited SASP and mitigated radiation ulcers in animal models. Our results demonstrate that inhibition of SASP from senescent cells by zileuton can effectively mitigate radiation-induced cutaneous ulcers, indicating that inhibition of 5-LO might be a viable strategy for patients with this condition.