Synthesis and evaluation of sulfate conjugated metronidazole as a colon specific prodrug of metronidazole.
Hyunjeong Kim*, Yonghyun Lee*, Hansun Yoo, Jihye Kim, Hyesik Kong, Jeong-Hyun Yoon, Yunjin Jung, Young-Mi Kim
Journal of drug targeting, 2012
52
Susceptibility of glucocorticoids to colonic metabolism and pharmacologic intervention in the metabolism: implication for therapeutic activity of colon-specific glucocorticoid 21-sulfate sodium at the target site.
Hyesik Kong, Yonghyun Lee, Hyunjeong Kim, Dae-Duk Kim, Jeong-Hyun Yoon, Yunjin Jung, Young-Mi Kim
Journal of pharmacy and pharmacology, 2012
53
Structural effects of N-aromatic acyl-amino acid conjugates on their deconjugation in the cecal contents of rats: implication in design of a colon-specific prodrug with controlled conversion rate at the target site.
Hyesik Kong, Hyunjeong Kim, Heejeong Do, Yonghyun Lee, Sungchae Hong, Jeong-Hyun Yoon, Yunjin Jung, Young-Mi Kim
Biopharmaceutics & drug disposition, 2011
54
Evaluation of dextran-flufenamic acid ester as a polymeric colon-specific prodrug of flufenamic acid, an anti-inflammatory drug, for chronotherapy.
Yonghyun Lee, In Ho Kim, Jeongyun Kim, Jeong-Hyun Yoon, Young Hee Shin, Yunjin Jung, Young-Mi Kim
Journal of drug targeting, 2011
55
Structural analysis of 5-aminosalicyl-L-glutamic Acid, a colon-specific prodrug of 5-aminosalicylic acid, for colon-specific deconjugation.
Ji-Hye Kim, Jung-Yoon Kim, Yonghyun Lee, Young-Mi Kim, Yunjin Jung
Journal of Pharmaceutical Investigation
56
Sulfate-conjugated methylprednisolone as a colon-targeted methylprednisolone prodrug with improved therapeutic properties against rat colitis.
Preparation and evaluation of microcrystallized cellulose xanthate-metal-oxytetracyclinecomplexes as antibacterial agents with prolonged antibacterial activity.
Hyo-Sik Kong, You-Na Lee, Yonghyun Lee, Young-Mi Kim, Yunjin Jung
Journal of Pharmaceutical Investigation
58
Dexamethasone 21-sulfate improves the therapeutic properties of dexamethasone against experimental rat colitis by specifically delivering the steroid to the large intestine.
Inho Kim, Hyesik Kong, Yonghyun Lee, Sungchae Hong, Jungoh Han, Sunhwa Jung, Yunjin Jung, Young-Mi Kim
Pharm Res, 2009
59
Sulfate-conjugated methylprednisolone: Evaluation as a colon-specific methylprednisolone prodrug and comparison with sulfate-conjugated prednisolone and dexamethasone.