Alpha rhythm and Alzheimer’s disease: Has Hans Berger’s dream come true?
Claudio Babiloni, Xianghong Arakaki, Sandra Báez, Robert J. Barry, Alberto Benussi, Katarzyna J. Blinowska, Laura Bonanni, Barbara Borroni, Jorge Bosch‐Bayard, Giuseppe Bruno, Alessia Cacciotti, Filippo Carducci, John Carino, Matteo Carpi, Antonella Conte, Josephine Cruzat, Fabrizia D’Antonio, Stefania Della Penna, Claudio Del Percio, Pierfilippo De Sanctis, Javier Escudero, Giovanni Fabbrini, Francesca R Farina, Francisco J. Fraga, Peter Fuhr, Ute Gschwandtner, Bahar Güntekin, Yi Guo, Mihály Hajós, Mark Hallett, Harald Hampel, Lűtfű Hanoğlu, Ira Haraldsen, Mahmoud Hassan, Christoffer Hatlestad‐Hall, András Attila Horváth, Agustín Ibáñez, Francesco Infarinato, Alberto Jaramillo-Jiménez, Jaeseung Jeong, Yang Jiang, Maciej Kamiński, Giacomo Koch, Sanjeev Kumar, Giorgio Leodori, Gang Li, Roberta Lizio, Susanna Lopez, Raffaele Ferri, Fernando Maestú, Camillo Marra, Laura Marzetti, William J. McGeown, Francesca Miraglia, Sebastián Moguilner, Davide Vito Moretti, Faisal Mushtaq, Giuseppe Noce, Lorenzo Nucci, John Fredy Ochoa-Gómez, Paolo Onorati, Alessandro Padovani, Chiara Pappalettera, Mario A. Parra, Matteo Pardini, Roberto D. Pascual‐Marqui, Walter Paulus, Vittorio Pizzella, Pavel Prado, Géraldine Rauchs, Petra Ritter, Marco Salvatore, Hernando Santamaría‐García, Michael Schirner, Andrea Soricelli, John‐Paul Taylor, Hatice Tankişi, Franca Tecchio, Stefan Teipel, Alpha Tom Kodamullil, Antonio Ivano Triggiani, Mitchell Valdés-Sosa, Pedro A. Valdés‐Sosa, Fabrizio Vecchio, Keith Vossel, Dezhong Yao, Görsev Yener, Ulf Ziemann, Anita Kamondi
IF 3.6
Clinical Neurophysiology
In this "centenary" paper, an expert panel revisited Hans Berger's groundbreaking discovery of human restingstate electroencephalographic (rsEEG) alpha rhythms (8-12 Hz) in 1924, his foresight of substantial clinical applications in patients with "senile dementia," and new developments in the field, focusing on Alzheimer's disease (AD), the most prevalent cause of dementia in pathological aging. Clinical guidelines issued in 2024 by the US National Institute on Aging-Alzheimer's Association (NIA-AA) and the European Neuroscience Societies did not endorse routine use of rsEEG biomarkers in the clinical workup of older adults with cognitive impairment. Nevertheless, the expert panel highlighted decades of research from independent workgroups and different techniques showing consistent evidence that abnormalities in rsEEG delta, theta, and alpha rhythms (< 30 Hz) observed in AD patients correlate with wellestablished AD biomarkers of neuropathology, neurodegeneration, and cognitive decline. We posit that these abnormalities may reflect alterations in oscillatory synchronization within subcortical and cortical circuits, inducing cortical inhibitory-excitatory imbalance (in some cases leading to epileptiform activity) and vigilance dysfunctions (e.g., mental fatigue and drowsiness), which may impact AD patients' quality of life. Berger's vision of using EEG to understand and manage dementia in pathological aging is still actual.