Analysis of Intracellular Golgi pH in CHO Cells Under Culture Process Conditions Using Ratiometric pH-Sensitive Fluorescent Proteins
J. H. Lee, J. Kim, J. H. Park, W. D. Heo, G. M. Lee
Biotechnol. Bioeng., 2019
52
Glyco-Engineered CHO Cell Lines Producing Alpha-1-Antitrypsin and C1 Esterase Inhibitor with Fully Humanized N-Glycosylation Profiles
T. Amann, A. H. Hansen, S. Kol, H. G. Hansen, J. Arnsdorf, S. Nallapareddy, B. Voldborg, G. M. Lee, M. R. Andersen, H. F. Kildegaard
Metabolic Eng., 2019
53
Improving the Production of Recombinant Bone Morphogenetic Protein-4 (BMP-4) by Removal of Autoregulatory Feedback Loop Using BMP Receptor-Knockout CHO Cell Lines
C. L. Kim, G. M. Lee
Metabolic Eng., 2019
54
Revealing Key Determinants of Clonal Variation in Transgene Expression in Recombinant CHO Cells Using Targeted Genome Editing
J. S. Lee, J. H. Park, T. K. Ha, M. Samoudi, N. E. Lewis, B. O. Palsson, H. F. Kildegaard, G. M. Lee
ACS Synth. Biol., 2018
55
Minimizing Clonal Variation During Mammalian Cell Line Engineering for Improved Systems Biology Data Generation
L. M. Grav, D. Sergeeva, J. S. Lee, I. M. de Mas, N. E. Lewis, M. R. Andersen, L. K. Nielsen, G. M. Lee, H. F. Kildegaard
ACS Synth. Biol., 2018
56
Differential Expression of microRNAs in Recombinant Chinese Hamster Ovary Cells Treated with Sodium Butyrate Using Digital RNA Counting
S. M. Lim, S. H. Park, J. H. Lee, S. H. Kim, J. Y. Kim, J. K. Min, G. M. Lee, Y. G. Kim
J. Biotechnol., 2018
57
Improving the Production of Recombinant Human Bone Morphogenetic Protein-4 in CHO Cell Cultures by Inhibition of Its Undesirable Endocytic Mechanism
C. L. Kim, M. Y. Jung, Y. S. Kim, J. W. Jang, G. M. Lee
Biotechnol. Bioeng., 2018
58
Untangling the Mechanism of 3-Methyladenine (3-MA) in enhancing the specific productivity: Transcriptomic analysis of a CHO cell line producing Fc-fusion protein treated with 3-MA
E. Baek, J. S. Lee, G. M. Lee
Biotechnol. Bioeng., 2018
59
CRISPR/Cas9-Multiplexed Editing of Chinese Hamster Ovary B4Gal-T1, 2, 3 and 4 Tailors N-Glycan Profiles of Therapeutics and Secreted Host Cell Proteins
T. Amann, A. H. Hansen, S. Ko, G. M. Lee, M. R. Andersen, H. F. Kildegaard
Biotechnol. J., 2018
60
Baicalein Reduces Oxidative Stress in CHO Cell Cultures and Improves Recombinant Antibody Productivity
T. K. Ha, A. H. Hansen, S. Kol, H. F. Kildegaard, G. M. Lee